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Relativepotencies of transporter inhibition are as follows: parox-etine > citalopram > sertraline > fl uvoxamine > fl uoxetine.At higher doses (for example, fl uoxetine ?60 mg daily),some SSRIs also inhibit reuptake of norepinephrine anddopamine, with sertraline having the greatest dopaminereuptake effect (Tulloch and Johnson, 1992). It is available fororal administration in film-coated tablets containing 5, 10,or 23 mg of donepezil hydrochloride and in ODT (orallydissolving tablet) formulation that contains 5 or 10 mg ofdonepezil administered once daily usually in the evening(if patients recall dreams, it may be switched to morn-ing). However, it may modify synapticrelease of glutamate/GABA by binding to a specificsynaptic protein labelled ‘SV2A’
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